Virtual Cortical Resection Reveals Push-Pull Network Control Preceding Seizure Evolution.

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TitleVirtual Cortical Resection Reveals Push-Pull Network Control Preceding Seizure Evolution.
Publication TypeJournal Article
Year of Publication2016
AuthorsKhambhati, AN, Davis, KA, Lucas, TH, Litt, B, Bassett, DS
JournalNeuron
Volume91
Issue5
Pagination1170-1182
Date Published2016 Sep 07
ISSN1097-4199
KeywordsAdolescent, Adult, Age of Onset, Brain, Child, Child, Preschool, Computer Simulation, Female, Humans, Male, Middle Aged, Neural Pathways, Seizures, Young Adult
Abstract

In ∼20 million people with drug-resistant epilepsy, focal seizures originating in dysfunctional brain networks will often evolve and spread to surrounding tissue, disrupting function in otherwise normal brain regions. To identify network control mechanisms that regulate seizure spread, we developed a novel tool for pinpointing brain regions that facilitate synchronization in the epileptic network. Our method measures the impact of virtually resecting putative control regions on synchronization in a validated model of the human epileptic network. By applying our technique to time-varying functional networks, we identified brain regions whose topological role is to synchronize or desynchronize the epileptic network. Our results suggest that greater antagonistic push-pull interaction between synchronizing and desynchronizing brain regions better constrains seizure spread. These methods, while applied here to epilepsy, are generalizable to other brain networks and have wide applicability in isolating and mapping functional drivers of brain dynamics in health and disease.

DOI10.1016/j.neuron.2016.07.039
Alternate JournalNeuron
PubMed ID27568515
PubMed Central IDPMC5017915
Grant ListR01 HD086888 / HD / NICHD NIH HHS / United States
R01 NS063039 / NS / NINDS NIH HHS / United States
R21 MH106799 / MH / NIMH NIH HHS / United States
U24 NS063930 / NS / NINDS NIH HHS / United States