Variable bandwidth filtering for improved sensitivity of cross-frequency coupling metrics.

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TitleVariable bandwidth filtering for improved sensitivity of cross-frequency coupling metrics.
Publication TypeJournal Article
Year of Publication2012
AuthorsBerman, JI, McDaniel, J, Liu, S, Cornew, L, Gaetz, W, Roberts, TPL, J Edgar, C
JournalBrain Connect
Volume2
Issue3
Pagination155-63
Date Published2012
ISSN2158-0022
KeywordsAction Potentials, Brain, Fourier Analysis, Humans, Models, Neurological, Nerve Net, Neurons
Abstract

There is an increasing interest in examining cross-frequency coupling (CFC) between groups of oscillating neurons. Most CFC studies examine how the phase of lower-frequency brain activity modulates the amplitude of higher-frequency brain activity. This study focuses on the signal filtering that is required to isolate the higher-frequency neuronal activity which is hypothesized to be amplitude modulated. In particular, previous publications have used a filter bandwidth fixed to a constant for all assessed modulation frequencies. The present article demonstrates that fixed bandwidth filtering can destroy amplitude modulation and create false-negative CFC measures. To overcome this limitation, this study presents a variable bandwidth filter that ensures preservation of the amplitude modulation. Simulated time series data were created with theta-gamma, alpha-gamma, and beta-gamma phase-amplitude coupling. Comparisons between filtering methods indicate that the variable bandwidth approach presented in this article is preferred when examining amplitude modulations above the theta band. The variable bandwidth method of filtering an amplitude modulated signal is proposed to preserve amplitude modulation and enable accurate CFC measurements.

DOI10.1089/brain.2012.0085
Alternate JournalBrain Connect
PubMed ID22577870
PubMed Central IDPMC3621836
Grant ListR01DC008871 / DC / NIDCD NIH HHS / United States
R01DC008871-02S1 / DC / NIDCD NIH HHS / United States
P30HD026979 / HD / NICHD NIH HHS / United States
K01 MH096091 / MH / NIMH NIH HHS / United States
K08 MH085100 / MH / NIMH NIH HHS / United States
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