A systematic review of treatments for anxiety in youth with autism spectrum disorders.

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TitleA systematic review of treatments for anxiety in youth with autism spectrum disorders.
Publication TypeJournal Article
Year of Publication2014
AuthorsVasa, RA, Carroll, LM, Nozzolillo, AA, Mahajan, R, Mazurek, MO, Bennett, AE, Wink, LK, Bernal, MPilar
JournalJ Autism Dev Disord
Date Published2014 Dec
KeywordsAdolescent, Anxiety, Child, Child Development Disorders, Pervasive, Citalopram, Clinical Trials as Topic, Cognitive Behavioral Therapy, Humans, Treatment Outcome

This study systematically examined the efficacy and safety of psychopharmacological and non-psychopharmacological treatments for anxiety in youth with autism spectrum disorders (ASD). Four psychopharmacological, nine cognitive behavioral therapy (CBT), and two alternative treatment studies met inclusion criteria. Psychopharmacological studies were descriptive or open label, sometimes did not specify the anxiety phenotype, and reported behavioral activation. Citalopram and buspirone yielded some improvement, whereas fluvoxamine did not. Non-psychopharmacological studies were mainly randomized controlled trials (RCTs) with CBT demonstrating moderate efficacy for anxiety disorders in youth with high functioning ASD. Deep pressure and neurofeedback provided some benefit. All studies were short-term and included small sample sizes. Large scale and long term RCTs examining psychopharmacological and non-psychopharmacological treatments are sorely needed.

Alternate JournalJ Autism Dev Disord
PubMed ID25070468
Grant ListUA3 MC 11054 / / PHS HHS / United States
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