Sex differences in network controllability as a predictor of executive function in youth.

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TitleSex differences in network controllability as a predictor of executive function in youth.
Publication TypeJournal Article
Year of Publication2019
AuthorsCornblath, EJ, Tang, E, Baum, GL, Moore, TM, Adebimpe, A, Roalf, DR, Gur, RC, Gur, RE, Pasqualetti, F, Satterthwaite, TD, Bassett, DS
JournalNeuroimage
Volume188
Pagination122-134
Date Published2019 03
ISSN1095-9572
Abstract

Executive function is a quintessential human capacity that emerges late in development and displays different developmental trends in males and females. Sex differences in executive function in youth have been linked to vulnerability to psychopathology as well as to behaviors that impinge on health, wellbeing, and longevity. Yet, the neurobiological basis of these differences is not well understood, in part due to the spatiotemporal complexity inherent in patterns of brain network maturation supporting executive function. Here we test the hypothesis that sex differences in impulsivity in youth stem from sex differences in the controllability of structural brain networks as they rewire over development. Combining methods from network neuroscience and network control theory, we characterize the network control properties of structural brain networks estimated from diffusion imaging data acquired in males and females in a sample of 879 youth aged 8-22 years. We summarize the control properties of these networks by estimating average and modal controllability, two statistics that probe the ease with which brain areas can drive the network towards easy versus difficult-to-reach states. We find that females have higher modal controllability in frontal, parietal, and subcortical regions while males have higher average controllability in frontal and subcortical regions. Furthermore, controllability profiles in males are negatively related to the false positive rate on a continuous performance task, a common measure of impulsivity. Finally, we find associations between average controllability and individual differences in activation during an n-back working memory task. Taken together, our findings support the notion that sex differences in the controllability of structural brain networks can partially explain sex differences in executive function. Controllability of structural brain networks also predicts features of task-relevant activation, suggesting the potential for controllability to represent context-specific constraints on network state more generally.

DOI10.1016/j.neuroimage.2018.11.048
Alternate JournalNeuroimage
PubMed ID30508681
PubMed Central IDPMC6401302
Grant ListR01 NS099348 / NS / NINDS NIH HHS / United States
R01 MH107235 / MH / NIMH NIH HHS / United States
R01 DC009209 / DC / NIDCD NIH HHS / United States
R21 MH106799 / MH / NIMH NIH HHS / United States
RF1 MH116920 / MH / NIMH NIH HHS / United States
R01 MH113550 / MH / NIMH NIH HHS / United States
K01 MH102609 / MH / NIMH NIH HHS / United States
R01 HD086888 / HD / NICHD NIH HHS / United States
R01 MH109520 / MH / NIMH NIH HHS / United States
R01 MH107703 / MH / NIMH NIH HHS / United States