Restricted and Repetitive Behavior and Brain Functional Connectivity in Infants at Risk for Developing Autism Spectrum Disorder.

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TitleRestricted and Repetitive Behavior and Brain Functional Connectivity in Infants at Risk for Developing Autism Spectrum Disorder.
Publication TypeJournal Article
Year of Publication2019
AuthorsMcKinnon, CJ, Eggebrecht, AT, Todorov, A, Wolff, JJ, Elison, JT, Adams, CM, Snyder, AZ, Estes, AM, Zwaigenbaum, L, Botteron, KN, Mckinstry, RC, Marrus, N, Evans, A, Hazlett, HC, Dager, SR, Paterson, SJ, Pandey, J, Schultz, RT, Styner, MA, Gerig, G, Schlaggar, BL, Petersen, SE, Piven, J, Pruett, JR
Corporate AuthorsIBIS Network
JournalBiol Psychiatry Cogn Neurosci Neuroimaging
Volume4
Issue1
Pagination50-61
Date Published2019 01
ISSN2451-9030
Abstract

BACKGROUND: Restricted and repetitive behaviors (RRBs), detectable by 12 months in many infants in whom autism spectrum disorder (ASD) is later diagnosed, may represent some of the earliest behavioral markers of ASD. However, brain function underlying the emergence of these key behaviors remains unknown.METHODS: Behavioral and resting-state functional connectivity (fc) magnetic resonance imaging data were collected from 167 children at high and low familial risk for ASD at 12 and 24 months (n = 38 at both time points). Twenty infants met criteria for ASD at 24 months. We divided RRBs into four subcategories (restricted, stereotyped, ritualistic/sameness, self-injurious) and used a data-driven approach to identify functional brain networks associated with the development of each RRB subcategory.RESULTS: Higher scores for ritualistic/sameness behavior were associated with less positive fc between visual and control networks at 12 and 24 months. Ritualistic/sameness and stereotyped behaviors were associated with less positive fc between visual and default mode networks at 12 months. At 24 months, stereotyped and restricted behaviors were associated with more positive fc between default mode and control networks. Additionally, at 24 months, stereotyped behavior was associated with more positive fc between dorsal attention and subcortical networks, whereas restricted behavior was associated with more positive fc between default mode and dorsal attention networks. No significant network-level associations were observed for self-injurious behavior.CONCLUSIONS: These observations mark the earliest known description of functional brain systems underlying RRBs, reinforce the construct validity of RRB subcategories in infants, and implicate specific neural substrates for future interventions targeting RRBs.

DOI10.1016/j.bpsc.2018.09.008
Alternate JournalBiol Psychiatry Cogn Neurosci Neuroimaging
PubMed ID30446435
PubMed Central IDPMC6557405
Grant ListU54 HD083091 / HD / NICHD NIH HHS / United States
R01 MH093510 / MH / NIMH NIH HHS / United States
U54 HD087011 / HD / NICHD NIH HHS / United States
P30 NS098577 / NS / NINDS NIH HHS / United States
U54 HD079124 / HD / NICHD NIH HHS / United States
U54 HD086984 / HD / NICHD NIH HHS / United States
K01 MH103594 / MH / NIMH NIH HHS / United States
K01 MH101653 / MH / NIMH NIH HHS / United States
R01 HD055741 / HD / NICHD NIH HHS / United States