Resting-state oscillatory activity in autism spectrum disorders.

We just began a large new study on
Autism, ADHD, Anxiety & Depression in 12-17 year-olds.
Read more and learn how you can help!

TitleResting-state oscillatory activity in autism spectrum disorders.
Publication TypeJournal Article
Year of Publication2012
AuthorsCornew, L, Roberts, TPL, Blaskey, L, J Edgar, C
JournalJ Autism Dev Disord
Volume42
Issue9
Pagination1884-94
Date Published2012 Sep
ISSN1573-3432
KeywordsAdolescent, Biological Clocks, Brain Mapping, Brain Waves, Cerebral Cortex, Child, Child Development Disorders, Pervasive, Female, Humans, Magnetoencephalography, Male
Abstract

Neural oscillatory anomalies in autism spectrum disorders (ASD) suggest an excitatory/inhibitory imbalance; however, the nature and clinical relevance of these anomalies are unclear. Whole-cortex magnetoencephalography data were collected while 50 children (27 with ASD, 23 controls) underwent an eyes-closed resting-state exam. A Fast Fourier Transform was applied and oscillatory activity examined from 1 to 120 Hz at 15 regional sources. Associations between oscillatory anomalies and symptom severity were probed. Children with ASD exhibited regionally specific elevations in delta (1-4 Hz), theta (4-8 Hz), alpha (8-12 Hz), and high frequency (20-120 Hz) power, supporting an imbalance of neural excitation/inhibition as a neurobiological feature of ASD. Increased temporal and parietal alpha power was associated with greater symptom severity and thus is of particular interest.

DOI10.1007/s10803-011-1431-6
Alternate JournalJ Autism Dev Disord
PubMed ID22207057
PubMed Central IDPMC3638261
Grant ListR01 DC008871 / DC / NIDCD NIH HHS / United States
R01DC008871 / DC / NIDCD NIH HHS / United States
R01DC008871-02S1 / DC / NIDCD NIH HHS / United States
P30 HD026979 / HD / NICHD NIH HHS / United States
T32 NS007413 / NS / NINDS NIH HHS / United States
T32NS007413 / NS / NINDS NIH HHS / United States
Comments
Leave a Comment