|Title||Rate and Risk Factors Associated with Autism Spectrum Disorder in Congenital Diaphragmatic Hernia.|
|Publication Type||Journal Article|
|Year of Publication||2018|
|Authors||Danzer, E, Hoffman, C, D'Agostino, JAnn, Miller, JS, Waqar, LN, Gerdes, M, Bernbaum, JC, Rosenthal, H, Rintoul, NE, Herkert, LM, Peranteau, WH, Flake, AW, N Adzick, S, Hedrick, HL|
|Journal||J Autism Dev Disord|
|Date Published||2018 Jan 30|
To determine the rate and predictors of autism spectrum disorder (ASD) in congenital diaphragmatic hernia (CDH). Between 06/2004 and 09/2015 a total of 110 CDH survivors underwent neurodevelopmental (ND) testing and screening for ASD, followed by a full autism diagnostic evaluation if indicated at our institution. We found a 9 time higher rate of ASD in CDH children compared to the general population (P = 0.0002). Multiple patient-related and clinical variables risk factors of ASD were identified by univariate analysis. However, only short-term and long-term neurodevelopmental delays were strongly associated with ASD in CDH by multivariate comparisons. There is a striking prevalence of ASD in CDH survivors and our findings suggest that all CDH children should be regularly screened for ASD.
|Alternate Journal||J Autism Dev Disord|