Profiles of Autonomic Activity in Autism Spectrum Disorder with and without Anxiety.

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TitleProfiles of Autonomic Activity in Autism Spectrum Disorder with and without Anxiety.
Publication TypeJournal Article
Year of Publication2021
AuthorsParma, V, Cellini, N, Guy, L, McVey, AJ, Rump, K, Worley, J, Maddox, BB, Bush, J, Bennett, A, Franklin, M, Miller, JS, Herrington, J
JournalJ Autism Dev Disord
Date Published2021 Feb 09
ISSN1573-3432
Abstract

Both anxiety and autism spectrum disorder (ASD) are associated with atypical physiological activity. Few studies have systematically assessed the resting physiological activity in ASD with co-occurring anxiety disorders. We tested 75 participants divided in four groups: youth with ASD, with (ASD + Anxiety = 22, 6F, 12.29 ± 2.83 years old) and without co-occurring anxiety (ASD Alone = 15, 6F, 11.59 ± 2.85 years old) and compared their physiological profile with that of matched typically developing controls (TDC) with (Anxiety Alone = 16, 6F, 11.24 ± 3.36 years old) and without co-occurring anxiety disorders (TDC = 22, 8F, 11.88 ± 2.88 years old). Results indicated reduced sympathetic and parasympathetic activity at rest in ASD as compared to TDC youth. ASD + Anxiety and Anxiety Alone groups showed different sympathetic, but similar parasympathetic activity. These findings suggest that autonomic profile-based approaches may advance research, diagnosis, and treatment of ASD and anxiety.

DOI10.1007/s10803-020-04862-0
Alternate JournalJ Autism Dev Disord
PubMed ID33565037
Grant List4100042728 / / Pennsylvania Department of Health /
P30 HD026979 / HD / NICHD NIH HHS / United States
RC1MH08879 / MH / NIMH NIH HHS / United States
R01 MH073084-01 / MH / NIMH NIH HHS / United States