A Pilot Study of Cardiovascular Reactivity in Children With Autism Spectrum Disorder.

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TitleA Pilot Study of Cardiovascular Reactivity in Children With Autism Spectrum Disorder.
Publication TypeJournal Article
Year of Publication2020
AuthorsAmoss, RToby, Leong, T, Evans, ANichole, Ousley, O, Herrington, JD, Lecavalier, L, Goodwin, MS, Hofmann, SG, Scahill, L
JournalSemin Pediatr Neurol
Volume34
Pagination100807
Date Published2020 Jul
ISSN1558-0776
Abstract

In preparation for a larger case-control study of children with autism spectrum disorder (ASD) and anxiety, we conducted a pilot study using a noninvasive electrocardiographic device to measure cardiovascular reactivity in 10 children (age range 9-14) with ASD. The 45-minute procedure included 6 conditions: baseline rest, an interview about school, interim rest, an unfair computerized ball-toss game followed by a fair version of the game, and a final rest. Data were successfully collected for 95% of all conditions. Omnibus Skillings-Mack tests suggested that heart rate variability variables including mean heart rate, mean RR interval, and root mean square of successive differences showed statistically significant variation across conditions. The procedure appears feasible and may be an informative biomarker of anxiety in ASD.

DOI10.1016/j.spen.2020.100807
Alternate JournalSemin Pediatr Neurol
PubMed ID32446441