Parvalbumin Cell Ablation of NMDA-R1 Leads to Altered Phase, But Not Amplitude, of Gamma-Band Cross-Frequency Coupling.

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TitleParvalbumin Cell Ablation of NMDA-R1 Leads to Altered Phase, But Not Amplitude, of Gamma-Band Cross-Frequency Coupling.
Publication TypeJournal Article
Year of Publication2019
AuthorsPort, RG, Berman, JI, Liu, S, Featherstone, RE, Roberts, TPL, Siegel, SJ
JournalBrain Connect
Date Published2019 04
KeywordsAnimals, Autism Spectrum Disorder, Disease Models, Animal, Electroencephalography, Electrophysiological Phenomena, Gamma Rhythm, Magnetic Resonance Imaging, Male, Mice, Mice, Inbred Strains, Parvalbumins, Receptors, N-Methyl-D-Aspartate, Rest

Altered gamma-band electrophysiological activity in individuals with autism spectrum disorder (ASD) is well documented, and analogous gamma-band alterations are recapitulated in several preclinical murine models relevant to ASD. Such gamma-band activity is hypothesized to underlie local circuit processes. Gamma-band cross-frequency coupling (CFC), a related though distinct metric, interrogates local neural circuit signal integration. Several recent studies have observed perturbed gamma-band CFC in individuals with ASD, although the direction of change remains unresolved. It also remains unclear whether murine models relevant to ASD recapitulate this altered gamma-band CFC. As such, this study examined whether mice with parvalbumin (PV) cell-specific ablation of NMDA-R1 (PV/NR1) demonstrated altered gamma-band CFC as compared with their control littermates (PV/NR1-mice that do not have the PV cell-specific ablation of NMDA-R1). Ten mice of each genotype had 4 min of "resting" electroencephalography recorded and analyzed. First, resting electrophysiological power was parsed into the canonical frequency bands and genotype-related differences were subsequently explored so as to provide context for the subsequent CFC analyses. PV/NR1 mice exhibited an increase in resting power specific to the high gamma-band, but not other frequency bands, as compared with PV/NR1. CFC analyses then examined both the standard magnitude (strength) of CFC and the novel metric Phase-which denotes the phase of the lower frequency signal at which the peak higher frequency signal power occurred. PV/NR1 mice exhibited altered Phase, but not strength, of gamma-band CFC as compared with PV/NR1 mice. As such, this study suggests a potential novel metric to explore when studying neuropsychiatric disorders.

Alternate JournalBrain Connect
PubMed ID30588822
PubMed Central IDPMC6479236
Grant ListP50 MH096891 / MH / NIMH NIH HHS / United States
T32 MH019112 / MH / NIMH NIH HHS / United States
R01 DC008871 / DC / NIDCD NIH HHS / United States
R21 MH110869 / MH / NIMH NIH HHS / United States
K01 MH096091 / MH / NIMH NIH HHS / United States
U54 HD086984 / HD / NICHD NIH HHS / United States