Olfactory Dysfunction in Neurodevelopmental Disorders: A Meta-analytic Review of Autism Spectrum Disorders, Attention Deficit/Hyperactivity Disorder and Obsessive-Compulsive Disorder.

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TitleOlfactory Dysfunction in Neurodevelopmental Disorders: A Meta-analytic Review of Autism Spectrum Disorders, Attention Deficit/Hyperactivity Disorder and Obsessive-Compulsive Disorder.
Publication TypeJournal Article
Year of Publication2020
AuthorsCrow, AJD, Janssen, JM, Vickers, KL, Parish-Morris, J, Moberg, PJ, Roalf, DR
JournalJ Autism Dev Disord
Volume50
Issue8
Pagination2685-2697
Date Published2020 Aug
ISSN1573-3432
KeywordsAttention Deficit Disorder with Hyperactivity, Autism Spectrum Disorder, Child, Female, Humans, Male, Obsessive-Compulsive Disorder, Olfaction Disorders, Smell
Abstract

Olfactory dysfunction is recognized in neurodevelopmental disorders and may serve as an early indicator of global dysfunction. The present meta-analysis measures olfaction effect sizes in attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorders (ASDs), and obsessive-compulsive disorder (OCD). Meta-analysis included 320 ADHD, 346 ASD, and 208 OCD individuals as compared to 910 controls. Olfactory performance deficits were small-to-moderate and heterogeneous (d =  - 0.42, 95% CI =  - 0.59 < δ <  - 0.25). Meta-analytic results indicate that olfactory dysfunction is evident in individuals with ASD and OCD, with small-to-negligible effects in ADHD. These findings imply olfactory dysfunction is related to clinical phenotype in ASD and OCD, but not ADHD, and warrant inclusion in clinical assessment and evaluation of certain neurodevelopmental disorders.

DOI10.1007/s10803-020-04376-9
Alternate JournalJ Autism Dev Disord
PubMed ID31960263
PubMed Central IDPMC7369237
Grant ListK01 MH102609 / MH / NIMH NIH HHS / United States
R01 MH119185 / MH / NIMH NIH HHS / United States
R21 MH108895 / MH / NIMH NIH HHS / United States
K01 MH102609 / MH / NIMH NIH HHS / United States
R01 MH119185 / MH / NIMH NIH HHS / United States