Left hemisphere diffusivity of the arcuate fasciculus: influences of autism spectrum disorder and language impairment.

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TitleLeft hemisphere diffusivity of the arcuate fasciculus: influences of autism spectrum disorder and language impairment.
Publication TypeJournal Article
Year of Publication2014
AuthorsRoberts, TPL, Heiken, K, Zarnow, D, Dell, J, Nagae, L, Blaskey, L, Solot, C, Levy, SE, Berman, JI, Edgar, JC
JournalAJNR Am J Neuroradiol
Volume35
Issue3
Pagination587-92
Date Published2014 Mar
ISSN1936-959X
KeywordsCerebrum, Child, Child Development Disorders, Pervasive, Diffusion Tensor Imaging, Female, Humans, Language Disorders, Male
Abstract

BACKGROUND AND PURPOSE: There has been much discussion whether brain abnormalities associated with specific language impairment and autism with language impairment are shared or are disorder specific. Although white matter tract abnormalities are observed in both specific language impairment and autism spectrum disorders, the similarities and differences in the white matter abnormalities in these 2 disorders have not been fully determined.MATERIALS AND METHODS: Diffusion tensor imaging diffusion parameters of the arcuate fasciculus were measured in 14 children with specific language impairment as well as in 16 children with autism spectrum disorder with language impairment, 18 with autism spectrum disorder without language impairment, and 25 age-matched typically developing control participants.RESULTS: Language impairment and autism spectrum disorder both had (elevating) main effects on mean diffusivity of the left arcuate fasciculus, initially suggesting a shared white matter substrate abnormality. Analysis of axial and radial diffusivity components, however, indicated that autism spectrum disorder and language impairment differentially affect white matter microstructural properties, with a main effect of autism spectrum disorder on axial diffusivity and a main effect of language impairment on radial diffusivity.CONCLUSIONS: Although white matter abnormalities appear similar in language impairment and autism spectrum disorder when examining broad white matter measures, a more detailed analysis indicates different mechanisms for the white matter microstructural anomalies associated with language impairment and autism spectrum disorder.

DOI10.3174/ajnr.A3754
Alternate JournalAJNR Am J Neuroradiol
PubMed ID24335547
PubMed Central IDPMC3970288
Grant ListNIH-R01DC008871 / DC / NIDCD NIH HHS / United States
R01 DC008871 / DC / NIDCD NIH HHS / United States
P30 HD026979 / HD / NICHD NIH HHS / United States
K01 MH096091 / MH / NIMH NIH HHS / United States
NIH-P30HD026979 / HD / NICHD NIH HHS / United States
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