Joint Attention and Brain Functional Connectivity in Infants and Toddlers.

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TitleJoint Attention and Brain Functional Connectivity in Infants and Toddlers.
Publication TypeJournal Article
Year of Publication2017
AuthorsEggebrecht, AT, Elison, JT, Feczko, E, Todorov, A, Wolff, JJ, Kandala, S, Adams, CM, Snyder, AZ, Lewis, JD, Estes, AM, Zwaigenbaum, L, Botteron, KN, Mckinstry, RC, Constantino, JN, Evans, A, Hazlett, HC, Dager, S, Paterson, SJ, Schultz, RT, Styner, MA, Gerig, G, Das, S, Kostopoulos, P, Schlaggar, BL, Petersen, SE, Piven, J, Pruett, JR
Corporate AuthorsIBIS Network†
JournalCereb Cortex
Date Published2017 03 01
KeywordsAttention, Brain, Brain Mapping, Child Development, Child, Preschool, Female, Humans, Infant, Magnetic Resonance Imaging, Male, Neural Pathways, Neuropsychological Tests, Psychology, Child

Initiating joint attention (IJA), the behavioral instigation of coordinated focus of 2 people on an object, emerges over the first 2 years of life and supports social-communicative functioning related to the healthy development of aspects of language, empathy, and theory of mind. Deficits in IJA provide strong early indicators for autism spectrum disorder, and therapies targeting joint attention have shown tremendous promise. However, the brain systems underlying IJA in early childhood are poorly understood, due in part to significant methodological challenges in imaging localized brain function that supports social behaviors during the first 2 years of life. Herein, we show that the functional organization of the brain is intimately related to the emergence of IJA using functional connectivity magnetic resonance imaging and dimensional behavioral assessments in a large semilongitudinal cohort of infants and toddlers. In particular, though functional connections spanning the brain are involved in IJA, the strongest brain-behavior associations cluster within connections between a small subset of functional brain networks; namely between the visual network and dorsal attention network and between the visual network and posterior cingulate aspects of the default mode network. These observations mark the earliest known description of how functional brain systems underlie a burgeoning fundamental social behavior, may help improve the design of targeted therapies for neurodevelopmental disorders, and, more generally, elucidate physiological mechanisms essential to healthy social behavior development.

Alternate JournalCereb. Cortex
PubMed ID28062515
PubMed Central IDPMC5452276
Grant ListU54 HD083091 / HD / NICHD NIH HHS / United States
P30 ES010126 / ES / NIEHS NIH HHS / United States
R01 MH093510 / MH / NIMH NIH HHS / United States
U54 HD087011 / HD / NICHD NIH HHS / United States
U54 HD086984 / HD / NICHD NIH HHS / United States
K01 MH103594 / MH / NIMH NIH HHS / United States
K01 MH101653 / MH / NIMH NIH HHS / United States