The Emergence of Network Inefficiencies in Infants With Autism Spectrum Disorder.

TitleThe Emergence of Network Inefficiencies in Infants With Autism Spectrum Disorder.
Publication TypeJournal Article
Year of Publication2017
AuthorsLewis, JD, Evans, AC, Pruett, JR, Botteron, KN, Mckinstry, RC, Zwaigenbaum, L, Estes, AM, D Collins, L, Kostopoulos, P, Gerig, G, Dager, SR, Paterson, S, Schultz, RT, Styner, MA, Hazlett, HC, Piven, J
Corporate AuthorsInfant Brain Imaging Study Network
JournalBiol Psychiatry
Volume82
Issue3
Pagination176-185
Date Published2017 Aug 01
ISSN1873-2402
KeywordsAutism Spectrum Disorder, Brain, Child, Preschool, Diffusion Magnetic Resonance Imaging, Female, Genetic Predisposition to Disease, Humans, Image Processing, Computer-Assisted, Infant, Linear Models, Longitudinal Studies, Male, Neural Pathways, Severity of Illness Index, Siblings, Sleep
Abstract

BACKGROUND: Autism spectrum disorder (ASD) is a developmental disorder defined by behavioral features that emerge during the first years of life. Research indicates that abnormalities in brain connectivity are associated with these behavioral features. However, the inclusion of individuals past the age of onset of the defining behaviors complicates interpretation of the observed abnormalities: they may be cascade effects of earlier neuropathology and behavioral abnormalities. Our recent study of network efficiency in a cohort of 24-month-olds at high and low familial risk for ASD reduced this confound; we reported reduced network efficiencies in toddlers classified with ASD. The current study maps the emergence of these inefficiencies in the first year of life.METHODS: This study uses data from 260 infants at 6 and 12 months of age, including 116 infants with longitudinal data. As in our earlier study, we use diffusion data to obtain measures of the length and strength of connections between brain regions to compute network efficiency. We assess group differences in efficiency within linear mixed-effects models determined by the Akaike information criterion.RESULTS: Inefficiencies in high-risk infants later classified with ASD were detected from 6 months onward in regions involved in low-level sensory processing. In addition, within the high-risk infants, these inefficiencies predicted 24-month symptom severity.CONCLUSIONS: These results suggest that infants with ASD, even before 6 months of age, have deficits in connectivity related to low-level processing, which contribute to a developmental cascade affecting brain organization and eventually higher-level cognitive processes and social behavior.

DOI10.1016/j.biopsych.2017.03.006
Alternate JournalBiol. Psychiatry
PubMed ID28460842
PubMed Central IDPMC5524449
Grant ListU54 HD083091 / HD / NICHD NIH HHS / United States
P30 ES010126 / ES / NIEHS NIH HHS / United States
R01 MH093510 / MH / NIMH NIH HHS / United States
U54 HD087011 / HD / NICHD NIH HHS / United States
U54 HD086984 / HD / NICHD NIH HHS / United States
R01 HD055741 / HD / NICHD NIH HHS / United States