Electrophysiological signatures: magnetoencephalographic studies of the neural correlates of language impairment in autism spectrum disorders.

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TitleElectrophysiological signatures: magnetoencephalographic studies of the neural correlates of language impairment in autism spectrum disorders.
Publication TypeJournal Article
Year of Publication2008
AuthorsRoberts, TPL, Schmidt, GL, Egeth, M, Blaskey, L, Rey, MM, J Edgar, C, Levy, SE
JournalInt J Psychophysiol
Volume68
Issue2
Pagination149-60
Date Published2008 May
ISSN0167-8760
KeywordsAcoustic Stimulation, Adolescent, Autistic Disorder, Brain Mapping, Child, Child, Preschool, Electroencephalography, Evoked Potentials, Auditory, Humans, Language Development Disorders, Magnetoencephalography, Reaction Time
Abstract

While magnetoencephalography (MEG) is of increasing utility in the assessment of pediatric patients with seizure disorders, this reflects only a part of the clinical potential of the technology. Beyond epilepsy, a broad range of developmental psychiatric disorders require the spatial and temporal resolution of brain activity offered by MEG. This article reviews the application of MEG in the study of auditory processing as an aspect of language impairment in children. Specifically, the potential application of MEG is elaborated in autism spectrum disorders (ASD), a devastating disorder with prevalence of 1 in 150. Results demonstrate the sensitivity of MEG for detection of abnormalities of auditory processing in ASD ('electrophysiological signatures') and their clinical correlates. These findings offer promise for the comprehensive assessment of developmental neuropsychiatric disorders.

DOI10.1016/j.ijpsycho.2008.01.012
Alternate JournalInt J Psychophysiol
PubMed ID18336941
PubMed Central IDPMC2397446
Grant ListR01 DC008871 / DC / NIDCD NIH HHS / United States
R01DC008871 / DC / NIDCD NIH HHS / United States
R01 DC008871-01 / DC / NIDCD NIH HHS / United States
T32 NS007413 / NS / NINDS NIH HHS / United States
T32NS007413 / NS / NINDS NIH HHS / United States
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