Brain state flexibility accompanies motor-skill acquisition.

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TitleBrain state flexibility accompanies motor-skill acquisition.
Publication TypeJournal Article
Year of Publication2018
AuthorsReddy, PG, Mattar, MG, Murphy, AC, Wymbs, NF, Grafton, ST, Satterthwaite, TD, Bassett, DS
JournalNeuroimage
Volume171
Pagination135-147
Date Published2018 May 01
ISSN1095-9572
Abstract

Learning requires the traversal of inherently distinct cognitive states to produce behavioral adaptation. Yet, tools to explicitly measure these states with non-invasive imaging - and to assess their dynamics during learning - remain limited. Here, we describe an approach based on a distinct application of graph theory in which points in time are represented by network nodes, and similarities in brain states between two different time points are represented as network edges. We use a graph-based clustering technique to identify clusters of time points representing canonical brain states, and to assess the manner in which the brain moves from one state to another as learning progresses. We observe the presence of two primary states characterized by either high activation in sensorimotor cortex or high activation in a frontal-subcortical system. Flexible switching among these primary states and other less common states becomes more frequent as learning progresses, and is inversely correlated with individual differences in learning rate. These results are consistent with the notion that the development of automaticity is associated with a greater freedom to use cognitive resources for other processes. Taken together, our work offers new insights into the constrained, low dimensional nature of brain dynamics characteristic of early learning, which give way to less constrained, high-dimensional dynamics in later learning.

DOI10.1016/j.neuroimage.2017.12.093
Alternate JournalNeuroimage
PubMed ID29309897
PubMed Central IDPMC5857429
Grant ListR01 HD086888 / HD / NICHD NIH HHS / United States
R01 NS099348 / NS / NINDS NIH HHS / United States
R21 MH106799 / MH / NIMH NIH HHS / United States
T32 MH017168 / MH / NIMH NIH HHS / United States