Associations between parental broader autism phenotype and child autism spectrum disorder phenotype in the Study to Explore Early Development.

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TitleAssociations between parental broader autism phenotype and child autism spectrum disorder phenotype in the Study to Explore Early Development.
Publication TypeJournal Article
Year of Publication2019
AuthorsRubenstein, E, Wiggins, LD, Schieve, LA, Bradley, C, DiGuiseppi, C, Moody, E, Pandey, J, Pretzel, REdmondson, Howard, AGreen, Olshan, AF, Pence, BW, Daniels, J
JournalAutism
Volume23
Issue2
Pagination436-448
Date Published2019 Feb
ISSN1461-7005
Abstract

The autism spectrum disorder phenotype varies by social and communication ability and co-occurring developmental, behavioral, and medical conditions. Etiology is also diverse, with myriad potential genetic origins and environmental risk factors. Examining the influence of parental broader autism phenotype-a set of sub-clinical characteristics of autism spectrum disorder-on child autism spectrum disorder phenotypes may help reduce heterogeneity in potential genetic predisposition for autism spectrum disorder. We assessed the associations between parental broader autism phenotype and child phenotype among children of age 30-68 months enrolled in the Study to Explore Early Development (N = 707). Child autism spectrum disorder phenotype was defined by a replication of latent classes derived from multiple developmental and behavioral measures: Mild Language Delay with Cognitive Rigidity, Mild Language and Motor Delay with Dysregulation (e.g. anxiety/depression), General Developmental Delay, and Significant Developmental Delay with Repetitive Motor Behaviors. Scores on the Social Responsiveness Scale-Adult measured parent broader autism phenotype. Broader autism phenotype in at least one parent was associated with a child having increased odds of being classified as mild language and motor delay with dysregulation compared to significant developmental delay with repetitive motor behaviors (odds ratio: 2.44; 95% confidence interval: 1.16, 5.09). Children of parents with broader autism phenotype were more likely to have a phenotype qualitatively similar to broader autism phenotype presentation; this may have implications for etiologic research.

DOI10.1177/1362361317753563
Alternate JournalAutism
PubMed ID29376397
PubMed Central IDPMC6027594
Grant ListU10 DD000180 / DD / NCBDD CDC HHS / United States
U10 DD000181 / DD / NCBDD CDC HHS / United States
U10 DD000184 / DD / NCBDD CDC HHS / United States
U01 DD001210 / DD / NCBDD CDC HHS / United States
U01 DD000498 / DD / NCBDD CDC HHS / United States
U01 DD001205 / DD / NCBDD CDC HHS / United States
CC999999 / / Intramural CDC HHS / United States
U54 HD086984 / HD / NICHD NIH HHS / United States
U10 DD000182 / DD / NCBDD CDC HHS / United States
P2C HD050924 / HD / NICHD NIH HHS / United States
U10 DD000183 / DD / NCBDD CDC HHS / United States