|Title||Amygdala Volume Differences in Autism Spectrum Disorder Are Related to Anxiety.|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||Herrington, JD, Maddox, BB, Kerns, CM, Rump, K, Worley, JA, Bush, JC, McVey, AJ, Schultz, RT, Miller, JS|
|Journal||J Autism Dev Disord|
|Date Published||2017 Dec|
Recent studies suggest that longstanding findings of abnormal amygdala morphology in ASD may be related to symptoms of anxiety. To test this hypothesis, fifty-three children with ASD (mean age = 11.9) underwent structural MRI and were divided into subgroups to compare those with at least one anxiety disorder diagnosis (n = 29) to those without (n = 24) and to a typically developing control group (TDC; n = 37). Groups were matched on age and intellectual level. The ASD and anxiety group showed decreased right amygdala volume (controlled for total brain volume) relative to ASD without anxiety (p = .04) and TDCs (p = .068). Results suggest that youth with ASD and co-occurring anxiety have a distinct neurodevelopmental trajectory.
|Alternate Journal||J Autism Dev Disord|