Abnormal auditory mismatch fields in adults with autism spectrum disorder.

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TitleAbnormal auditory mismatch fields in adults with autism spectrum disorder.
Publication TypeJournal Article
Year of Publication2019
AuthorsMatsuzaki, J, Ku, M, Berman, JI, Blaskey, L, Bloy, L, Chen, Y-H, Dell, J, J Edgar, C, Kuschner, ES, Liu, S, Saby, J, Brodkin, ES, Roberts, TPL
JournalNeurosci Lett
Volume698
Pagination140-145
Date Published2019 04 17
ISSN1872-7972
KeywordsAcoustic Stimulation, Adult, Auditory Perception, Autism Spectrum Disorder, Humans, Magnetoencephalography, Male, Young Adult
Abstract

The auditory mismatch field (MMF) is a pre-attentive processing component, reflecting neural discrimination and inhibitory processing. Abnormal MMFs have been reported in children with autism spectrum disorder (ASD) along with an association with abnormal language comprehension; however, relatively little is known about MMF abnormalities to contrasting vowel stimuli in adults with ASD. To better understand the neurophysiological mechanisms underlying auditory language discrimination of vowel stimuli in individuals with ASD, magnetoencephalography was used to measure MMFs during an auditory oddball paradigm with vowel stimuli (/a/ and /u/) in adults with ASD. MMFs arising from left and right superior temporal gyrus are reported from nine high-functioning right handed males with ASD (22.22 ± 5.74yrs) and sixteen typically developing (TD) right handed males (27.25 ± 6.63yrs). The MMF was delayed in adults with ASD (188.90 ± 5.8 ms) as compared to the TD participants (173.08 ± 4.31 ms, p < 0.05). Replicating previous findings in children, the earlier M100 component to single stimulus tokens was also delayed in adults with ASD (108.59 ± 4.1 ms) compared to the TD participants (94.60 ± 3.0 ms, p < 0.05). However, there was no correlation between delayed M100 latency and MMF latency. Furthermore, whereas TD participants showed a leftward lateralization of MMF amplitude, participants with ASD showed an opposite (rightward) lateralization. Findings suggest that adults with ASD have hemispherically- and temporally- abnormal auditory discrimination processing in addition to and distinct from abnormal neurophysiological mechanisms in earlier cortical responses.

DOI10.1016/j.neulet.2018.12.043
Alternate JournalNeurosci. Lett.
PubMed ID30599264
PubMed Central IDPMC6435410
Grant ListR01 DC008871 / DC / NIDCD NIH HHS / United States
U54 HD086984 / HD / NICHD NIH HHS / United States
UL1 RR024134 / RR / NCRR NIH HHS / United States